Paper

Using AuNPs-modified screen-printed electrode in the development of molecularly imprinted polymer for artificial bioreceptor fabrication to improve biosensor sensitivity for 17β-estradiol detection

, and

Published 20 March 2019 © 2019 Vietnam Academy of Science & Technology
, , Citation T N Lien Truong et al 2019 Adv. Nat. Sci: Nanosci. Nanotechnol. 10 015015 DOI 10.1088/2043-6254/ab0d1b

2043-6262/10/1/015015

Abstract

In this work, we reported on the development of a sensor platform for the detection of 17β-Estradiol (E2). The artificial receptors for targets were fabricated on gold nanoparticles (AuNPs)-modified screen-printed carbon ink electrode. This is an applicable technical solution to overcome main limitations of current membrane molecularly imprinted polymer (MIP) technology. The AuNPs layer will increase specific area of electrode, hence increasing number of imprinted analyte molecules to polymer membrane. Especially, the harmonic distribution of AuNPs on the electrode helps to generate a single oriented monomer layer on the electrode. In turn, this layer helps to generate a highly homogeneous membrane of polymer with thickness of only several single layers to easily remove imprinted molecules from polymer matrix to form highly specific cavities, thus increasing the efficiency of the fabrication of artificial MIP bioreceptors. Our fabricated sensors showed the capability of detection limit (LOD) of 2 fM. The sensor also demonstrated reduced cost (cost of carbon ink printed electrode but can use as gold ink printed electrode), detection platform simplicity, and high reproducibility.

Export citation and abstract BibTeX RIS

Access this article

The computer you are using is not registered by an institution with a subscription to this article. Please choose one of the options below.

Login

IOPscience login

Find out more about journal subscriptions at your site.

Purchase from

Article Galaxy
CCC RightFind

Purchase this article from our trusted document delivery partners.

Make a recommendation

To gain access to this content, please complete the Recommendation Form and we will follow up with your librarian or Institution on your behalf.

For corporate researchers we can also follow up directly with your R&D manager, or the information management contact at your company. Institutional subscribers have access to the current volume, plus a 10-year back file (where available).

10.1088/2043-6254/ab0d1b