Porous scaffolds based on biogenic poly (ε-caprolactone)/ hydroxyapatite composites: In vivo study

Salma M Naga


Each year million tons of fish bones and shellfish are caught, which were causing a serious environmental problem. Although these wastes contain valuable minerals, their use is not widespread. The main objective of the present study is the evaluation of the in vitro and in vivo behaviour of the extracted poly (ε-caprolactone) /nano-hydroxyapatite composites porous scaffolds. PCL /HA composites were prepared by an impregnation method, and the optimized composites were implanted in adult male albino (Sprague-Dawley strain) rats. The studied composites were evaluated as bone substitutes or fillers, and their degradation products were studied via biological and surgical examination. In vivo tests and biochemical studies were conducted to observe the changes found in blood. Biological studies indicated that the degradation products of the PCL /HA scaffolds did not cause liver disorder, kidney failure, carcinogenic effect, oxidative effect and did not cause the liberation of oxygen radicals that could destroy the tissues. It also showed no inflammatory effect.


Biogenic hydroxyapatite, Porous scaffolds, In vitro, In vivo.

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Published by: IOP Publishing and Vietnam Academy of Science and Technology
Frequency: Articles appear online as they are published with print copies published 4 times per year
ISSN: Print: 2043-6254; Online: 2043-6262
DOI Range: 10.1088/issn.2043-6262

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