Microwave-assisted dextran modification and nanoparticle synthesis for application in drug delivery system

Hai Doan Do, Thi Thu Huong Le, Hong Nam Pham, Thu Phuong Ha

Abstract


Magnetic nanoparticles (MNPs) have attracted a lot of interest thanks to their small size, supermagnetism and low toxicity. However, with their large surface area, MNPs tend to aggregate and are sensitive to oxidation. To overcome this drawback, one of the solutions is surface modification of MNPs using many kinds of coating materials. Among them, carboxymethyl dextran is commonly used due to its high density of carboxymethyl groups which provide negative charge for stabilizing the ferrofluid and are available for attaching bioactive molecules. In this study we describe new methods of using microwave in carboxymethylation and Fe3O4 MNPs synthesis. Curcumin was then loaded on the coated MNPs to form a drug delivery system. The systems then were characterized and tested for cytotoxicity on cancer cells. Results show that our drug delivery system had small size of about 15-20 nm and saturation magnetization of 48.6 emu.g-1. Moreover, our system had strong anticancer effect against Hep-G2 and LU-1 cancer cell lines. Therefore, it can be a promising candidate for a novel anticancer treatment.


Keywords


carboxymethyl dextran, magnetic nanoparticles, curcumin

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Published by: IOP Publishing and Vietnam Academy of Science and Technology
Frequency: Articles appear online as they are published with print copies published 4 times per year
ISSN: Print: 2043-6254; Online: 2043-6262
DOI Range: 10.1088/issn.2043-6262

© Copyright 2016 Advances in Natural Sciences: Nanoscience and Nanotechnology